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Description
ELP3 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen ELP3 Synonyms Elongator complex protein 3; hELP3; tRNA uridine(34) acetyltransferase Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q9H9T3 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, MCF7, K562, Jurkat, Neuro 2a, C6, COS 7 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | ELP3 |
| Synonyms | Elongator complex protein 3; hELP3; tRNA uridine(34) acetyltransferase |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q9H9T3 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, MCF7, K562, Jurkat, Neuro-2a, C6, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| ICC | 1:100 | Hu, Ms |
Background
ELP3 (Elongator complex protein 3, also known as KAT9) is the catalytic histone acetyltransferase subunit of the highly conserved Elongator complex (composed of ELP1–ELP6) that associates with RNA polymerase II to facilitate transcriptional elongation via acetylation of histones H3 and H4, while also exhibiting cytoplasmic roles in α-tubulin acetylation to regulate neuronal migration and axonal branching, modifying wobble uridines in tRNAs to enhance translational efficiency, and participating in DNA demethylation after fertilization, cell migration, and redox homeostasis through acetylation of glucose-6-phosphate dehydrogenase, with its dysfunction implicated in neurodevelopmental disorders and tumor progression.
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