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Description
IL-17A Protein, MouseProduct Specification Species Mouse Synonyms Interleukin 17A; IL 17; IL 17A; Cytotoxic T Lymphocyte Associated Antigen 8; CTLA 8; IL17A; CTLA8; IL17 Accession Q62386 Amino Acid Sequence Thr22 Ala158 , with 6His tag at the C terminus Expression System HEK293 Molecular Weight 17 26 KDa, reducing conditions Purity >95% by SDS PAGE Endotoxin <0. 01EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH 7. 4.
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17 |
| Accession | Q62386 |
| Amino Acid Sequence | Thr22-Ala158 , with 6His tag at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 17-26 KDa, reducing conditions |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.01EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH 7.4. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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