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Description
7-DHC/DHCR7 Recombinant Rabbit mAb (S-3625-32)Product Specification Host Rabbit Antigen 7 DHC DHCR7 Synonyms 7 dehydrocholesterol reductase; Cholesterol 5,6 epoxide hydrolase subunit DHCR7; Sterol Delta (7) reductase; Dhcr7 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession O88455 Clone Number S 3625 32 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms, Rt Positive Sample Mouse testis, Mouse brain, Rat testis, Rat brain Purification Protein A Concentration 2
Product Specification
| Host | Rabbit |
| Antigen | 7-DHC/DHCR7 |
| Synonyms | 7-dehydrocholesterol reductase; Cholesterol-5,6-epoxide hydrolase subunit DHCR7; Sterol Delta (7)-reductase; Dhcr7 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | O88455 |
| Clone Number | S-3625-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms, Rt |
| Positive Sample | Mouse testis, Mouse brain, Rat testis, Rat brain |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
Background
7-Dehydrocholesterol (7-DHC) is a crucial sterol intermediate in the cholesterol biosynthesis pathway that serves as the direct precursor to cholesterol and the provitamin for vitamin D3 synthesis upon exposure to UVB radiation, while DHCR7 (7-dehydrocholesterol reductase) is the essential membrane-bound enzyme located in the endoplasmic reticulum that catalyzes the final step of this pathway by reducing the C7-C8 double bond of 7-DHC to produce cholesterol; together, they form a tightly regulated metabolic axis where genetic defects or inhibition of DHCR7 lead to the pathological accumulation of 7-DHC and its derivatives, causing severe developmental disorders such as Smith-Lemli-Opitz syndrome (SLOS) characterized by intellectual disability and congenital malformations, whereas under normal physiological conditions, the precise balance maintained by DHCR7 ensures adequate cellular cholesterol levels for membrane integrity and steroid hormone production while simultaneously controlling the pool of 7-DHC available for cutaneous photconversion to vitamin D3.
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4.5 ★★★★★
Based on 842 reviews
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Product Reviews
★★★★★ 5
Lovely Book!
Format: Hardcover
Written as a companion to Advent and Christmastide, I could not wait until then to start reading this book. Lanier Ivester's writing is compelling and thought-provoking. Jennifer Trafton's art throughout the book is rich and beautiful. The writing and art accompanied by recipes, menus, devotional suggestions, music recommendations, and craft ideas make this a book I will be pulling out year after year. "Look now, for glad and golden hours come swiftly on the wing. O rest beside the weary road and hear the angels sing."
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Reviewed in the United States on October 9, 2024
★★★★★ 5
Luminous reflections for the glad and golden hours of Christmastide
Format: Hardcover
Lanier Ivester's Glad and Golden Hours is a beautiful advent companion filled with tempting recipes, helpful holiday tips, and luminous reflections upon the "bright sadness" of the holiday season. Her lovely writing is wise and earnest and kindled my heart to imagine how I might savor the glad and golden hours of Christmastide this year.
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Reviewed in the United States on October 5, 2024
★★★★★ 5
wisdom infused with beauty and grace
Format: Hardcover
Whether you’re facing this Advent with great anticipation or overwhelming grief, Glad and Golden Hours will prove a sweet companion for the season. Interspersed with Lanier Ivester’s essays are holiday recipes and craft ideas, along with illustrations by Jennifer Trafton. A collection of wisdom infused with beauty and grace that I’ll return to year after year!
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Reviewed in the United States on October 19, 2024
★★★★★ 5
You need this book
Format: Hardcover
I didn't want to like this book, thinking it would be another how-to-have-the perfect-Christmas book. It's not that. I liked it so much I bought it for my friends. It's an exquisitely beautiful, thoughtful, joyful week by week story of preparation for the celebration of the Nativity. The author shares her own traditions, her recipes, book lists and song lists in a week-by-week format of suggestions that are easily adaptable to your own family situation. Perhaps most important, she shares her experience of deep grief in a season when joy is expected. No matter your life situation - single, married with little or big children, empty nester - Glad and Golden Hours can be like sitting with a friend for a few minutes a day, a friend who encourages you to take time for what's really important, to take joy where you find it, to maybe rethink what Advent and the Christmas season mean for you (and your family.) I ended up loving this book I didn't even want to like.
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Reviewed in the United States on December 23, 2024
★★★★★ 5
Excellent
Format: Paperback, Format: Paperback
Wonderful book that just got better as it went on, with the last three chapters being my favorites! In today's distracted, entertainment-tainted culture, it may seem impossible but is imperative for us to cultivate quiet in our lives. Most of us know this, yet we still shun such moments of hush even when a way shows itself open to us. As Sarah wrote, we hold our phones as a shield, protecting ourselves from "the chill nakedness of our discontent and shame, our fear and desire". In her insightful book, Sarah asks us, "Have you stood like a watchman on the walls of your heart through the witching hour of dusk when the horizons of productivity and familiarity give way to some vast realm just beyond your understanding, a realm that is both your terror and your deep desire?"
Yet, as Sarah so rightly points out, we do not only meet ourselves in that vast, spacious place of quiet; we meet God, "that great word speaking us back into life" and "the light burning at the back of our eyes so that we look upon the world in the brightness of his companionship".
Sarah's book is a treasure of her own personal stories and struggles, and the insights birthed from the living of them. One of my favorite chapters was the Wise Woman's Cottage, an excellent analogy for the gift of imagination, one of the gifts of quiet Sarah explores in her book's concluding chapters. The way she weaves the story of C. S. Lewis into her contemplations brought tears to my eyes.
Yet, the chapter that drew those tears out of my eyes was the following one in which Sarah shared a true story akin (at least in my mind) to that of Lucy's in Prince Caspian, a story that calls us to courage and obedience in heeding God's voice, even when the message comes only to us. "When I listen for God's voice, I find he doesn't just speak generally; he speaks particularly, to me. Quiet restores us to the wondrous autonomy of finding that God truly does come to speak to those who love him as Father and Friend. Of course, we listen, and that kind of listening can change the course of our lives...There is only one Voice whose words will always tell us true". Such wondrous words, though, can call on our courage to obey when those on the outside of God's inner promptings lack His perspective on the matter. Sarah's personal story in this chapter burned my eyes with sympathy and - when I read the encouragement she received -joy.
The last chapter of this potent book was one I would not have guessed to move me as it did. The reminder that quiet "offers the space in which we may give voice to" our anguish and wrestling "so that they do not destroy us" because, "in God's hands...our lament becomes the companion leading us to the source of our lost joy". Oh, how true. Oh, how beautiful: that quiet offers us the gift of lament, which is itself a grace as "it bears at heart the belief in the reality of joy" (a truth Sarah's sister, Joy Clarkson, explored in her insightful book Aggressively Happy, in which I was reminded that sadness speaks truth to us just as joy does; we are sad because of a loss we *should* be enjoying, something we were meant to have or experience, which will one day be redeemed). In offering our laments up to God, we can then hear his words of comfort, truth, hope and assurance just as Job did, but quiet is necessary for such a divine exchange to be experienced.
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Reviewed in the United States on November 12, 2024