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Description
BTN1A1/Butyrophilin Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BTN,BT,BTN1 Accession Q13410 1 Amino Acid Sequence Ala27 Arg242 with hIgG1 Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 55 70kDa (Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Human |
| Synonyms | BTN,BT,BTN1 |
| Accession | Q13410-1 |
| Amino Acid Sequence | Ala27-Arg242 with hIgG1 Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Chen B, Li K, Wang X, Zhang W, Han S, Zhang Y, Wang Y, Pang X, Xie Q, Lu J, Jiang S, Zhang S, Lv J. Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions. Nutrients. 2025 Sep 30;17(19):3131. |
Background
BTN1A1 (also known as butyrophilin subfamily 1 member A1) is a 55 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. Its structure includes extracellular IgV/IgC domains, a transmembrane region, and a cytoplasmic tail containing a B30.2 domain. Functionally, the B30.2 domain binds to xanthine oxidoreductase (XOR) to regulate milk fat globule secretion, while also serving as an intracellular phosphoantigen sensor to activate γδ T cells. Additionally, BTN1A1 inhibits CD4+ T cell proliferation, reduces the secretion of cytokines such as IL-2 and IFN-γ, and demonstrates protective effects in experimental autoimmune encephalomyelitis (EAE) models. Given its structural similarity to the B7 family and its involvement in immune regulation, BTN1A1 represents a potential novel co-stimulatory/inhibitory molecule and a promising therapeutic target for autoimmune and immune-related diseases.
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