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Description
Frizzled-5/FZD5 His Tag Protein, HumanProduct Specification Species Human Synonyms Frizzled 5, FZD5, C2orf3, Fz 5, hFz5, FzE5 Accession Q13467 Amino Acid Sequence Ala27 Pro167, with C terminal 8*His ASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPGGGSHHHHHHHH Expression System HEK293 Molecular Weight 25 33kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical
Product Specification
| Species | Human |
| Synonyms | Frizzled-5, FZD5, C2orf3, Fz-5, hFz5, FzE5 |
| Accession | Q13467 |
| Amino Acid Sequence | Ala27-Pro167, with C-terminal 8*His ASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 25-33kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Sun Y. et al. (2020) FZD5 contributes to TNBC proliferation, DNA damage repair and stemness. Cell Death and Disease. 11: 1060. |
Background
FZD5, a member in Frizzled family, was identified to be preferentially expressed in TNBC (triple-negative breast cancer), and associated with unfavorable prognosis. Loss and gain of function studies revealed that FZD5 contributed to TNBC cell G1/S transition, DNA replication, DNA damage repair, survival, and stemness. Mechanistically, transcription factor FOXM1, which promoted BRCA1 and BIRC5 transcription, acted as a downstream effecter of FZD5 signaling. FOXM1 overexpression in FZD5-deficient/low TNBC cells induced FZD5-associated phenotype. Finally, Wnt7B, a specific ligand for FZD5, was shown to be involved in cell proliferation, DNA damage repair, and stemness. Taken together, FZD5 is a novel target for the development of therapeutic strategies to overcome chemoresistance and prevent recurrence in TNBC.
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4.4 ★★★★★
Based on 2325 reviews
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Product Reviews
★★★★★ 4
Great lotion and absorbant
Size: 0.42 Fl Oz (Pack of 6)
Grewt lotion and price point. Storage last winter a few lotions absorbed air wuality. A 3 or 4 pack nay be more work better.?
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Reviewed in the United States on February 19, 2026
★★★★★ 5
Quality
Size: 0.42 Fl Oz (Pack of 6)
The very best skin cream on the market. The smell is very nice, not overwhelming at all. It leaves your skin feeling so soft and smelling good.
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Reviewed in the United States on January 24, 2026
★★★★★ 5
Glow and fight crepey neck!
Size: 0.42 Fl Oz (Pack of 6)
Favorite in my routine. I love Vaseline lotions and this is a perfect last step to my neck and hands every morning. Gives a boost of hydration and a nice glow to my neck. I think this is keeping me from crepey neck skin. Gotta fight that ladies! I use this several times a day and have it to all my friends for Xmas.
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Reviewed in the United States on January 28, 2026
★★★★★ 5
Nice glow
Size: 0.42 Fl Oz (Pack of 6)
Love it will order again just what I was looking for gives you a nice glow.
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Reviewed in the United States on May 16, 2026
★★★★★ 3
Something is different
Size: 0.42 Fl Oz (Pack of 6)
Product seems okay, but something has changed about it. Perhaps a different ingredient. Something different about the smell and texture. Still smells good, not greesy, and absorbs into skin like the past products I have purchased, but definitely something has changed.
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Reviewed in the United States on November 8, 2025