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Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
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Description
MRP2 Recombinant Rabbit mAb (S-2316-41)Product Specification Host Rabbit Antigen MRP2 Synonyms ATP binding cassette sub family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance associated protein 2; CMOAT; CMOAT1; CMRP; ABCC2 Immunogen Synthetic Peptide Location Cell membrane Accession Q92887 Clone Number S 2316 41 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | MRP2 |
| Synonyms | ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2; CMOAT; CMOAT1; CMRP; ABCC2 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q92887 |
| Clone Number | S-2316-41 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | A549, HepG2, A204, mouse liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:1000 | Hu |
Background
MRP2 (Multidrug Resistance-associated Protein 2), also known as ABCC2, is a 1,545-amino-acid ATP-binding cassette (ABC) transporter localized almost exclusively to the apical (canalicular) membrane of hepatocytes, where it functions as the primary efflux pump for conjugated organic anions including bilirubin glucuronides, glutathione conjugates, and a wide array of xenobiotics such as anticancer drugs, antibiotics, and environmental toxins, thereby playing a central role in hepatic detoxification and limiting the systemic exposure of tissues to these compounds; genetic mutations in the ABCC2 gene lead to Dubin–Johnson syndrome, a benign autosomal recessive disorder characterized by conjugated hyperbilirubinemia and black liver, whereas acquired MRP2 down-regulation contributes to cholestasis and multidrug resistance in cancer chemotherapy, and its expression is transcriptionally regulated by nuclear receptors like PXR, CAR, and FXR that respond to endobiotics and xenobiotics, making MRP2 a critical determinant of pharmacokinetics, drug–drug interactions, and bile formation.
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