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Description
PPIA Recombinant Rabbit mAb (S-2406-28)Product Specification Host Rabbit Antigen PPIA Synonyms Peptidyl prolyl cis trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A binding protein; Rotamase A; CYPA Immunogen Synthetic Peptide Location Secreted, Cytoplasm, Nucleus Accession P62937 Clone Number S 2406 28 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Positive Sample K562, HeLa, Jurkat, HepG2, A431, NIH 3T3, EL4, C2C12, mouse brain,
Product Specification
| Host | Rabbit |
| Antigen | PPIA |
| Synonyms | Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; CYPA |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cytoplasm, Nucleus |
| Accession | P62937 |
| Clone Number | S-2406-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, HeLa, Jurkat, HepG2, A431, NIH/3T3, EL4, C2C12, mouse brain, mouse heart, mouse kidney, mouse spleen |
| Predicted Reactivity | Ct, Bv, CtTa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
| ICFCM | 1:500 | Hu, Ms |
Background
PPIA (peptidyl-prolyl cis-trans isomerase A), also called cyclophilin A, is a 165-amino-acid, ubiquitously expressed cytoplasmic enzyme that catalyzes the cis-trans isomerization of prolyl peptide bonds and thus accelerates protein folding; beyond this chaperone-like role, it is a critical virulence factor for HIV-1, because the viral capsid recruits PPIA to shield itself from host restriction factors, while extracellular PPIA, secreted under inflammatory or oxidative stress, acts as a chemoattractant for monocytes and T cells via CD147/EMMPRIN, thereby amplifying inflammatory cascades in cardiovascular disease, viral infection, and cancer.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.3 ★★★★★
Based on 2029 reviews
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Product Reviews
★★★★★ 5
Soft keyboards ( updated)
The keys fell off very easily after only 2.5 months of use. It is a nice and smooth keyboard. I like it, but it didn't last even 3 months. I am trying to get it repaired by them since it was so recent that I got it- I will update this review later once I hear from the manufacturer.
This is an update to my original post. I am extremely impressed with the quality of customer service and how fast they addressed my concerns regarding the product and they honestly back up their product. Not only did they respond fast, but they also replace my keyboard. Not just fix it, replaced the whole thing and it is also backed by their manufacturer warranty. I’m so happy and love that I get to have my keyboard back to use for hopefully a lot longer this time. It truly is a comfort keyboard and I love how smooth the keys feel when typing for long periods of time. Thanks guys for the prompt response!
Today 3/27/2026 I received my brand new keyboard to replaced the one with the broken keys and I’m so happy to it back again and fully working thanks guys for the great customer service. Truly appreciate it.
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Reviewed in the United States on March 24, 2026
★★★★★ 5
Great keyboard at the right price
I bought this to replace my old Logi Ergo K860. I like the idea of curved keyboard. But the distance between my left and right hands on Ergo K860 was bothering me ever since I bought it 5 years ago. I would say I never got used to it. The Ergo started to act up one day with one key F not working properly. I tried to fix it and considered getting another one, then I saw this keyboard with a much better price. So I took the chance and went with this cheaper option. I like this one better than Ergo for the following reason:
1. The layout is more comfortable. Yes, it took me a while to get used to it like I would with any keyboard. I don't have to twist my wrists to reach any keys.
2. Keys are not too loud. It's not going to silent, but better than Ergo.
3. Battery life is great. I make a living by typing my keyboard. I only charged this keyboard once so far (4 months).
4. The price is great for what I got.
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Reviewed in the United States on September 7, 2025
★★★★★ 4
Good keyboard, some auxiliary keys are moved from where I was used to
I've only been using this for a day, so I can't speak about battery life. It is rechargeable, and it has an on-off switch for saving the battery when I'm not using it, so I don't know what more I could ask for on that front. Likes: the main keyboard is definitely ergonomic and feels comfortable; the key action is not silent, which I actually like, and the scissor action switches underneath the keys feels good to me; the keyboard is about 1.5" narrower than my previous keyboard (Logitech Ergo K860) because the number pad is right next to the regular part of the keyboard, and the usual keys in between have been rearranged. Most of these changes will just require the user to get used to the new positions. However, the Home, End, Pgup and Pgdn keys are now Function keys, piggybacking on the arrow keys, and that may cause more trouble for people who use those a lot (I don't, so I don't mind it). Dislikes: experience has shown me that dust and crud get into the space between the wrist pad and the rest of the keyboard. On my old keyboard, I could remove the wrist pad using some tiny screws in the back, and take the pad out for thorough cleaning. With this keyboard I won't be able to do that, so time will tell how aggravating that will be. Maybe I'll have to take it down to my shop and blow out the crud with the air compressor (joking, probably not a good idea). Overall, not quite 5 stars, but close. If it lasts better than the Logitech, I may come back and put in that last star.
Update: It has lasted about 20 months, and I'm going to have to replace it. I may buy another one, 20 months is pretty good for the amount of use I have gotten out of it, but I'm going to search to see if anything new and better is around. Symptoms seem to indicate that the rechargeable battery is not taking a charge any more. The keyboard works find when it is plugged in, but when I unplug it, after a few minutes it goes wacky.
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Reviewed in the United States on May 16, 2024
★★★★★ 1
Arrived Battery DOA - But then something unexpected happened.
This was a one star review because the unit arrived with a batter that would not hold charge for more than a minute. I am not changing the stars, because if you are like me, you read the one star reviews cause so many companies pay for fake 4 and 5 star reviews.
When I first posted this review I also initiated a return and just planned to move on to another brand. I was surprised when I got a personal email from the Arctek Service Team offering to send me a replacement free of charge. With nothing to lose I figured why not?
The new unit arrived and I put a full charge on it and put it to work. I chose this keyboard because it is the closest in layout to the original Microsoft ergo split keyboard, no longer in production, that I have used for years and truly enjoy. I am pleased to report that the battery is working fine and the keyboard performs flawlessly. No skipped strokes or stuck keys, no glitches with the proprietary wireless interface to the laptop (when I am using it on the desk with a large screen).
My hat is off to the Arctek service team and management. A company that cares enough about its reputation and customers to go to so much effort to take care of a customer with such a small dollar item sale is a company you can expect to rely on. From now on when I want electronic gear on Amazon, I am going to use the word Arctek in my search.
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Reviewed in the United States on April 9, 2026
★★★★★ 5
Incredible
1 year update: I have been using this keyboard daily at work for almost one year and my 5 star review stands. Upon receiving the keyboard I charged it before use, and since then I have not charged it at all and it is still somehow at 75% battery!! I turn it off at night when I’m done.
One of the function keys broke off in a way where I can’t reattach it, but I reached out to customer support and they sent me a free replacement keyboard. Great customer service and warranty!
Original review: I love this keyboard. I am a grant writer so I write and edit all day. It has really leveled up my typing experience and has made work much more comfortable. It puts my hands in a natural position so my wrists no longer bend at odd angles. I adapted to the split key design in minutes. The keys have an excellent feel and sound to them and the wrist pad feels like a soft cloud. I’ve had no connectivity issues and so far the battery has been stellar. It also has rubber grippers on the bottom so it stays firmly in place on my desk and doesn’t move around like my old keyboard did. I went for this one because I didn’t want to spend $100+ on a keyboard and I’m really impressed with the quality.
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Reviewed in the United States on September 6, 2024
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