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Description
GluN3B Recombinant Rabbit mAb (S-2320-3)Product Specification Host Rabbit Antigen GluN3B Synonyms Glutamate receptor ionotropic, NMDA 3B; GRIN3B Immunogen Recombinant Protein Location Cell membrane Accession O60391 Clone Number S 2320 3 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms Positive Sample CHO transfected with GluN3B Myc His fusion protein Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | GluN3B |
| Synonyms | Glutamate receptor ionotropic, NMDA 3B; GRIN3B |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | O60391 |
| Clone Number | S-2320-3 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | CHO transfected with GluN3B-Myc-His fusion protein |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Ms |
| ICC | 1:500 | Ms |
Background
GluN3B, encoded by the GRIN3B gene, is a unique and atypical subunit of the N-methyl-D-aspartate receptor (NMDAR) that fundamentally alters the receptor's functional properties when co-assembled with obligatory GluN1 subunits and conventional GluN2 subunits. Unlike other NMDAR subunits, GluN3B contains a distinct ligand-binding domain that renders the resulting heterotrimeric or heterotetrameric receptors insensitive to the co-agonist glycine and significantly reduces their calcium permeability and single-channel conductance, effectively acting as a dominant-negative modulator that dampens excitatory synaptic transmission. Primarily expressed in specific brain regions such as the thalamus, striatum, and during early postnatal development in the cortex, GluN3B plays a critical role in refining neural circuits by limiting excessive NMDAR activity, thereby influencing processes like synaptic plasticity, motor coordination, and sensory gating; furthermore, dysregulation or mutations in GRIN3B have been implicated in various neurological disorders, including schizophrenia, Huntington's disease, and rare forms of epilepsy, highlighting its importance as a potential therapeutic target for modulating glutamatergic signaling without completely abolishing NMDAR function.
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