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Ships within 48 hours · Estimated delivery Jul 8 - Jul 13
For Your Every Summer RSVP, with Code: SUMMER15
Description
TKT Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen TKT Synonyms Transketolase; TK Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession P29401 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample 293T, U 2 OS, HepG2, HeLa, Jurkat, NIH 3T3, mouse brain, PC 12, rat liver Predicted Reactivity Or, CyMk, Cz Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | TKT |
| Synonyms | Transketolase; TK |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | P29401 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | 293T, U-2 OS, HepG2, HeLa, Jurkat, NIH/3T3, mouse brain, PC-12, rat liver |
| Predicted Reactivity | Or, CyMk, Cz |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Transketolase (TKT) is a thiamine-diphosphate-dependent homodimeric enzyme encoded by the TKT gene on chromosome 3p21.1 that catalyzes reversible transfer of a two-carbon ketol group between ketose and aldose sugar phosphates, thereby linking the pentose phosphate pathway to glycolysis, generating NADPH and ribose-5-phosphate for nucleotide biosynthesis, and playing a central metabolic role in all organisms from bacteria to humans. Altered TKT activity—observed in diabetes and many cancers—makes it a potential therapeutic target, as its inhibition (e.g., by oxythiamine) suppresses cancer cell growth and thiamine supplementation can restore deficient activity .
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