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Description
NGAL Recombinant Rabbit mAb (SDT-473-49)Product Specification Host Rabbit Synonyms Lipocalin 2, Neutrophil gelatinase associated lipocalin Immunogen Recombinant Protein Accession P80188 Clone Number SDT 473 49 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA, CLIA Reactivity Hu Cross Reactivity No cross reactivity against CRP and KIM 1 Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS
Product Specification
| Host | Rabbit |
| Synonyms | Lipocalin-2, Neutrophil gelatinase-associated lipocalin |
| Immunogen | Recombinant Protein |
| Accession | P80188 |
| Clone Number | SDT-473-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA, CLIA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against CRP and KIM-1 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Neutrophil gelatinase-associated lipocalin (NGAL) is a 21-kD protein of the lipocalin superfamily. NGAL is a critical component of innate immunity to bacterial infection and is expressed by immune cells, hepatocytes and renal tubular cells in various disease states. NGAL is a small secreted polypeptide that is protease resistant and thus may be easily detected in the urine. Neutrophil gelatinase-associated lipocalin (Ngal, also known as lcn2) was identified as one of the most upregulated genes in the early post-ischaemic mouse kidney, a finding that has now been confirmed in several other transcriptome profiling studies following ischaemic and nephrotoxic kidney injuries. Downstream proteomic studies have also revealed NGAL to be one of the earliest and most robustly induced proteins in the kidney after ischaemic or nephrotoxic AKI in animal models. Importantly, NGAL protein is easily detected in the blood and urine soon after AKI in pre-clinical studies. These findings have initiated a number of translational studies to evaluate NGAL as a novel biomarker in human AKI.
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