Human IGFBP5 Protein, His Tag
SKU: 20410436595

Human IGFBP5 Protein, His Tag

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Description

Human IGFBP5 Protein, His TagProduct Specification Species Human Synonyms Insulin like growth factor binding protein 5, IBP 5, IGF binding protein 5, IGFBP 5, IBP5 Accession P24593 Amino Acid Sequence Protein sequence (P24593, Leu21 Glu272, with C His Tag)

Product Specification


Species Human
Synonyms Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5, IBP5
Accession P24593
Amino Acid Sequence

Protein sequence (P24593, Leu21-Glu272, with C-His Tag) LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
Expression System HEK293
Molecular Weight Predicted MW: 30.3 kDa Observed MW: 40 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Insulin-like growth factor-binding protein 5 (IGFBP5) is a key member of the IGFBP family, which regulates the bioavailability and activity of insulin-like growth factors (IGFs). Expressed in various tissues, IGFBP5 modulates cell proliferation, differentiation, and apoptosis through IGF-dependent and IGF-independent mechanisms. It interacts with extracellular matrix components and influences signaling pathways like MAPK and PI3K. IGFBP5 is implicated in physiological processes (e.g., bone development, wound healing) and pathologies, including cancer and fibrosis.

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Exchange/Return Notes
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SKU: 20410436595

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4.4 ★★★★★
Based on 476 reviews
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J
Verified Purchase
Jordan
Bozeman, US
★★★★★ 1
Pieces off in minutes.
Color: Origin - Large, Size: Medium/Large Dog
My pup chewed pieces off in minutes.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 6, 2026
A
Verified Purchase
Amazon Customer
West Palm Beach, US
★★★★★ 3
Pretty hard to clean
Color: Cinamutt Roll - Large, Size: Large
We've had this for about a week now. I have 2 dogs, one small one about 55lb. I bought this for my big girl, but lil man is determined to get the best of this toy. Usually they don't both go after the same toys, so this is interesting. The trouble is, neither one of them can get all the treats out if something makes it all the way down into the crevice. It's surprisingly deep. The up side is that they'll try for quite a while before giving up. The down side is even if you put it in the top rack of the dishwasher, something stuck deep in there isn't going anywhere until you dig it out yourself. I tried a plastic knife but it broke the second time I used it in there. I wound up using the metal handle of a reusable straw cleaner. Which then I had to wash that, too. Then it needs to dry overnight before it can be used again. All in all, the dogs like it fine, it's gross to scrape out and wash, takes longer than most toys to dry, and I have the feeling that will eventually cause me to pass it to someone else's dog long before my two have gotten tired of it. At this point I'm pulling out of the toy rotation for a week or two because I'm not ready to clean it a third time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 16, 2024
D
Verified Purchase
Dogmom120
Fort Morgan, US
★★★★★ 5
Hyena Proof
Color: Acorn - Large, Size: Large
I have an American Bulldog that would chew a brick if he didn’t have an alternative lying around. They won’t last forever (nothing does) but we’ve had two of these over the course of a year and for him that is nothing short of a miracle. And that is daily chewing like it’s his job. I highly recommend the Acornucopia for aggressive chewers with jaws like hyenas…so it’s probably great for your dog too.
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Reviewed in the United States on June 7, 2026
C
Verified Purchase
Clint Work
New York, US
★★★★★ 5
Love Barkbox!
Color: Comet - Small, Size: Small
I can't recommend Barkbox Super Chewer dog toys enough for those that have a pet that loves to chew. They are durable!!
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Reviewed in the United States on April 24, 2026
V
Verified Purchase
Victoria R.
Lake Worth, US
★★★★★ 5
This is an awesome product and affordably priced! I'll buy more in the future!
Color: Comet - Small, Size: Small
This is a great ball for my dog Polly! It doesn't stink or have any weird oils on the ball. It is definitely durable. It has a nice chirping sound and it's great exercise for my dog's jaws. It's not too bouncy and it's the perfect weight that she feels satisfied having in her mouth and when she catches it in mid-air. It's not too heavy that I have to worry about it knocking her teeth out. I almost cancelled the order after I found out the size of the ball, I thought it was a larger ball that Bark makes. It turns out it is larger than a tennis ball which is what I wanted. Someone gave us a black, knobby, ball that is 12.5 inches in diameter and she absolutely loves it, it's her favorite ball. It's the perfect size for her American Pit Bull mouth! I cannot find this product anywhere or a comparable alternative that's the same size. If you know where I can purchase another ball that I've described @ 12.5 in. diameter, please let me know! I'll likely buy this ball that was just delivered, today, in the future, if it's not discontinued! It's a great deal for only $14.99!! Thanks from a happy satisfied customer, V.B.
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Reviewed in the United States on April 23, 2024

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