human bsep vesicle kit hek293
SKU: 81744815182

human bsep vesicle kit hek293

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Description

human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich

Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
 
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
 

Transporter-Profil

Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)

Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten

Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)

Bekannte Substrate:  Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze

In stock: Human, Katze, Hund
 

Kit-Inhalt (100 Reaktionen)

  • Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
  • AMP-ATP-Lösung (100 mM), Cell4Pharma
  • Assay-Puffer, Cell4Pharma

Anwendungen

  • allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
  • Drug-Induced Liver Injury (DILI) Screening 
  • Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien 
  • Substratidentifikation für hepatische Efflux-Transporter
  • High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)

Regulatorische Konformität

Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
 

Technische Spezifikationen 

Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
 

Verwandte Produkte

  • Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
  • Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
  • Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
  • ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
  • Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 81744815182

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Patricia
Lowell, US
★★★★★ 5
COOLING MEMORY FOAM PILLOW
Size: Queen
THESE PILLOW ARE GREAT!! THEY SEND A SMALL POUCH OF ADDITIONAL FOAM THAT CAN BE ADDED WHEN YOU NEED TO ADJUST TO YOUR COMFORT. THEY STAY COOL AND THAT IS THE BEST THING FOR THAT PERSON WHO IS ALWAYS HOT.
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Reviewed in the United States on April 1, 2026
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Kyle
New York, US
★★★★★ 5
No stiff neck-- just as promised!
Size: Queen
Like most people I have tried all kinds of pillows to receive my stiff neck--to no avail. I decided to spend the extra money on this (since it was returnable) expecting it not to deliver, but in hopes that it would. I am happy to say the pillow provides great support, yet is fluffy and malleable. It looks a little flat out of the box, but give it an hour or so and it expands to full "fluff". The pillow is very comfortable, provides amazing support despite its soft, fluffy feel. Not being sculpted or rigid foam, it is easy to adjust and get the right support. Somehow it works! I have not had a stiff neck since I bought this. I did add about half the bag of extra material, but removed some because it was a little too much for me. The stuffing is clean, uniform and looks pristine. It comes with a beautiful pillow case that is thick and smooths out any "lumps" (which there aren't anyway because the filling is so soft and uniform.) I plan to order another one for our other home. Highly recommend.
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Reviewed in the United States on February 12, 2026
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Stephanie
Birmingham, US
★★★★★ 5
Great quality, not cheap but totally worth this price!
Size: King
I bought this pillow for my husband because the other I’ve purchased have gone flat. So far he is loving this pillow. It has great loft and comes with extra to adjust if necessary. I’m going to purchase one for myself as well! It is extremely comfortable!
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Reviewed in the United States on January 8, 2026
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CGB
Battle Creek, US
★★★★★ 4
You have to reposition to stay cool
Size: Queen
It's okay...it isn't much better than other cooling pillows I have had. If I had known you can't wash this pillow, only the outside cover, I would not have paid so much. The cover is cool to touch but the heat from your head will penetrate the pillow and I am constantly having to turn it over. So it is ok but way overpriced.
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Reviewed in the United States on August 14, 2025
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Francoara B Bauer
New York, US
★★★★★ 5
I like my Sujo FlexCool pillow
Size: Queen
It cools nicely and it is possible to add or remove fill to optimize preferred comfort. Quality made and very comfortable for me after I added some of the fill provided with the pillow.
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Reviewed in the United States on December 5, 2025

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